PreciMind Reference Change Value Intelligence System (PM-RCVIS)
Clinical decision intelligence for evaluating significant change between serial laboratory results — RCV computation, biological variation, trend analysis, and clinical interpretation.
PM-RCVIS is a deterministic reference change value intelligence system. It implements the Fraser–Harris RCV formula (Z × √2 × √(CVa² + CVi²)), biological variation quality goals per EFLM/Milan hierarchy, index of individuality computation, multi-point trend analysis with sequential significance testing, and clinical interchangeability risk simulation. All computations are reproducible and publication-grade.
Primary Inputs
Serial Data Points
0 addedAdd serial measurements for multi-point trend analysis. R1 and R2 above are used for single-comparison; add additional time points here for longitudinal analysis.
Data Sources for CVi
- • EFLM Biological Variation Database (biologicalvariation.eu)
- • Fraser CG. Biological Variation: From Principles to Practice. AACC Press, 2001.
- • Ricos C et al. Scand J Clin Lab Invest 1999;59:491–500.
Ready for analysis
Enter R1, R2, CVa, and CVi, then run the PM-RCVIS pipeline to receive full RCV computation, biological variation quality goals, clinical interpretation, and trend analysis.